TY - GEN
T1 - Ultrasound current source density imaging using a clinical intracardiac catheter
AU - Li, Qian
AU - Qin, Yexian
AU - Ingram, Pier
AU - Witte, Russell
AU - Wang, Zhaohui
PY - 2011
Y1 - 2011
N2 - Radiofrequency catheter ablation for treatment of cardiac arrhythmia requires pre-surgical mapping of the heart's activation wave. However, modern cardiac mapping systems continue to suffer from significant limitations. We have proposed Ultrasound Current Source Density Imaging (UCSDI) as a new modality to map reentry currents in the heart. In this study, we focus on interfacing UCSDI with a clinical intra-cardiac catheter - a key step towards translating UCSDI to the clinic for guiding cardiac ablation therapy. Sensitivity of UCSDI combined with the catheter was tested in a tissue mimicking phantom and fresh excised porcine hear tissue. Effect of the recoding distance on the detection of UCSDI was also investigated. Sensitivity of UCSDI with catheter was 4.7 μV/mA (R 2 = 0.999) in cylindrical gel (0.9% NaCl), and 3.2 μV/mA (R 2 = 0.92) in porcine heart tissue. The AE signal was detectable more than 25 mm away from the source in cylindrical gel (0.9% NaCl).
AB - Radiofrequency catheter ablation for treatment of cardiac arrhythmia requires pre-surgical mapping of the heart's activation wave. However, modern cardiac mapping systems continue to suffer from significant limitations. We have proposed Ultrasound Current Source Density Imaging (UCSDI) as a new modality to map reentry currents in the heart. In this study, we focus on interfacing UCSDI with a clinical intra-cardiac catheter - a key step towards translating UCSDI to the clinic for guiding cardiac ablation therapy. Sensitivity of UCSDI combined with the catheter was tested in a tissue mimicking phantom and fresh excised porcine hear tissue. Effect of the recoding distance on the detection of UCSDI was also investigated. Sensitivity of UCSDI with catheter was 4.7 μV/mA (R 2 = 0.999) in cylindrical gel (0.9% NaCl), and 3.2 μV/mA (R 2 = 0.92) in porcine heart tissue. The AE signal was detectable more than 25 mm away from the source in cylindrical gel (0.9% NaCl).
KW - ECG, EKG, multi-electrode recording
KW - acoustoelectric effect
KW - cardiac arrhythmia
KW - catheter ablation
UR - http://www.scopus.com/inward/record.url?scp=84869034302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869034302&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2011.0171
DO - 10.1109/ULTSYM.2011.0171
M3 - Conference contribution
AN - SCOPUS:84869034302
SN - 9781457712531
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 704
EP - 707
BT - 2011 IEEE International Ultrasonics Symposium, IUS 2011
T2 - 2011 IEEE International Ultrasonics Symposium, IUS 2011
Y2 - 18 October 2011 through 21 October 2011
ER -