TY - JOUR
T1 - Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter
AU - Qin, Yexian
AU - Li, Qian
AU - Ingram, Pier
AU - Barber, Christy
AU - Liu, Zhonglin
AU - Witte, Russell S.
N1 - Publisher Copyright:
© 1964-2012 IEEE.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.
AB - Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method for mapping electrical current in 4-D (space + time). This technique potentially overcomes limitations with conventional electrical mapping procedures typically used during treatment of sustained arrhythmias. However, the weak AE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 $\mu$V/MPa) than 1.0 MHz (0.42 $\mu$V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activation maps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of real-time 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.
UR - http://www.scopus.com/inward/record.url?scp=84919919325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919919325&partnerID=8YFLogxK
U2 - 10.1109/TBME.2014.2345771
DO - 10.1109/TBME.2014.2345771
M3 - Article
C2 - 25122512
AN - SCOPUS:84919919325
SN - 0018-9294
VL - 62
SP - 241
EP - 247
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 1
M1 - 6873233
ER -