TY - JOUR
T1 - Ultrasensitive Detection of Human Chorionic Gonadotropin Using Frequency Locked Microtoroid Optical Resonators
AU - Ozgur, Erol
AU - Roberts, Kara Ellen
AU - Ozgur, Ekin Ozge
AU - Gin, Adley Nathanael
AU - Bankhead, Jaden Robert
AU - Wang, Zhikun
AU - Su, Judith
N1 - Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2019/9/17
Y1 - 2019/9/17
N2 - Clean sport competition is of significant concern to many governments and sporting organizations. Highly sensitive and rapid sensors are needed to improve the detection of performance enhancing drugs in sports as athletes take diuretics to dilute the concentration of drugs in their urine and microdose under the detectable limits of current sensors. Here we demonstrate, using frequency locked microtoroid optical resonators, a 3 orders of magnitude improvement in detection limit over the current gold standard, mass spectrometry, for the common performance enhancing drug, human chorionic gonadotropin (hCG). hCG, also known as the pregnancy hormone, was detected both in simulated urine and in the urine of pregnant donors at a concentration of 1 and 3 femtomolar, respectively. We anticipate that the sensitivity provided by frequency locked optical microcavities can enable a new standard in antidoping research.
AB - Clean sport competition is of significant concern to many governments and sporting organizations. Highly sensitive and rapid sensors are needed to improve the detection of performance enhancing drugs in sports as athletes take diuretics to dilute the concentration of drugs in their urine and microdose under the detectable limits of current sensors. Here we demonstrate, using frequency locked microtoroid optical resonators, a 3 orders of magnitude improvement in detection limit over the current gold standard, mass spectrometry, for the common performance enhancing drug, human chorionic gonadotropin (hCG). hCG, also known as the pregnancy hormone, was detected both in simulated urine and in the urine of pregnant donors at a concentration of 1 and 3 femtomolar, respectively. We anticipate that the sensitivity provided by frequency locked optical microcavities can enable a new standard in antidoping research.
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U2 - 10.1021/acs.analchem.9b02630
DO - 10.1021/acs.analchem.9b02630
M3 - Article
C2 - 31415150
AN - SCOPUS:85072368941
SN - 0003-2700
VL - 91
SP - 11872
EP - 11878
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 18
ER -