Ubiquitin-specific peptidase 22 functions and its involvement in disease

Johanna Melo-Cardenas; Yusi Zhang; Donna D. Zhang; Deyu Fang

doi:10.18632/oncotarget.8602

Ubiquitin-specific peptidase 22 functions and its involvement in disease

Johanna Melo-Cardenas, Yusi Zhang, Donna D. Zhang, Deyu Fang

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis. Since this posttranslational modification plays a role in several different cellular functions, its deregulation has been associated with different pathologies. Aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis and neurological disorders. However, little is known about USP22 role in these pathologies or in normal physiology. This review summarizes the current knowledge about USP22 function from yeast to human and provides an overview of the possible mechanisms by which USP22 is emerging as a potential oncogene.

Original language	English (US)
Pages (from-to)	44848-44856
Number of pages	9
Journal	Oncotarget
Volume	7
Issue number	28
DOIs	https://doi.org/10.18632/oncotarget.8602
State	Published - 2016

Keywords

Ataxia
Cancer
Deubiquitylation
Oncogene
USP22

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.8602

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abstract = "Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis. Since this posttranslational modification plays a role in several different cellular functions, its deregulation has been associated with different pathologies. Aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis and neurological disorders. However, little is known about USP22 role in these pathologies or in normal physiology. This review summarizes the current knowledge about USP22 function from yeast to human and provides an overview of the possible mechanisms by which USP22 is emerging as a potential oncogene.",

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AU - Melo-Cardenas, Johanna

AU - Zhang, Yusi

AU - Zhang, Donna D.

AU - Fang, Deyu

N1 - Funding Information: This work was supported by research grants from National Institute of Health grants to D.F. and the National Institute of Environmental Health Sciences (NIEHS) (ES015010) and the American Cancer Society (RSG-07-154) awarded to D.D.Z.

PY - 2016

Y1 - 2016

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AB - Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis. Since this posttranslational modification plays a role in several different cellular functions, its deregulation has been associated with different pathologies. Aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis and neurological disorders. However, little is known about USP22 role in these pathologies or in normal physiology. This review summarizes the current knowledge about USP22 function from yeast to human and provides an overview of the possible mechanisms by which USP22 is emerging as a potential oncogene.

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Ubiquitin-specific peptidase 22 functions and its involvement in disease

Abstract

Keywords

ASJC Scopus subject areas

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