Types of natural selection and tests of selection

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Natural selection leaves distinct signals at loci in the genome that have experienced deleterious or advantageous mutations during their evolution. This chapter provides an overview of the main signatures left by natural selection both at the level of genetic variation within populations and at the level of differences between species. The chapter also details a number of classic summary statistics that exploit these signals to detect and quantify natural selection and the rationale behind these statistics. As such, it offers a basic introduction.

Original languageEnglish (US)
Title of host publicationHuman Population Genomics
Subtitle of host publicationIntroduction to Essential Concepts and Applications
PublisherSpringer International Publishing
Number of pages18
ISBN (Electronic)9783030616465
ISBN (Print)9783030616441
StatePublished - Apr 14 2021


  • Background selection
  • Balancing selection
  • Haplotype
  • Hitchhiking
  • Selective sweep
  • Site frequency spectrum

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Mathematics
  • General Medicine


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