Abstract
Natural selection leaves distinct signals at loci in the genome that have experienced deleterious or advantageous mutations during their evolution. This chapter provides an overview of the main signatures left by natural selection both at the level of genetic variation within populations and at the level of differences between species. The chapter also details a number of classic summary statistics that exploit these signals to detect and quantify natural selection and the rationale behind these statistics. As such, it offers a basic introduction.
Original language | English (US) |
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Title of host publication | Human Population Genomics |
Subtitle of host publication | Introduction to Essential Concepts and Applications |
Publisher | Springer International Publishing |
Pages | 69-86 |
Number of pages | 18 |
ISBN (Electronic) | 9783030616465 |
ISBN (Print) | 9783030616441 |
DOIs | |
State | Published - Apr 14 2021 |
Externally published | Yes |
Keywords
- Background selection
- Balancing selection
- Haplotype
- Hitchhiking
- Selective sweep
- Site frequency spectrum
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Mathematics
- General Medicine