Two‐locus approach of segregation and linkage analysis in the study of complex traits

Jianfeng Xu; Eugene W. Taylor; Carolien I.M. Panhuysen; Valerie L. Prenger; Rebecca Koskela; Bart Kiemeney; Michele C. LaBuda; Nancy E. Maestri; Deborah A. Meyers

doi:10.1002/gepi.1370120649

Two‐locus approach of segregation and linkage analysis in the study of complex traits

Jianfeng Xu, Eugene W. Taylor, Carolien I.M. Panhuysen, Valerie L. Prenger, Rebecca Koskela, Bart Kiemeney, Michele C. LaBuda, Nancy E. Maestri, Deborah A. Meyers

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A two‐locus segregation and linkage‐analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two‐locus Mendelian model fit the data significantly better than a one‐locus model. The linkage results based on the most parsimonious two‐locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one‐locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two‐locus models. © 1995 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	825-830
Number of pages	6
Journal	Genetic Epidemiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/gepi.1370120649
State	Published - 1995
Externally published	Yes

Keywords

linkage analysis
oligogenic model
segregation analysis
two‐locus

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.1370120649

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title = "Two‐locus approach of segregation and linkage analysis in the study of complex traits",

abstract = "A two‐locus segregation and linkage‐analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two‐locus Mendelian model fit the data significantly better than a one‐locus model. The linkage results based on the most parsimonious two‐locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one‐locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two‐locus models. {\textcopyright} 1995 Wiley‐Liss, Inc.",

keywords = "linkage analysis, oligogenic model, segregation analysis, two‐locus",

author = "Jianfeng Xu and Taylor, {Eugene W.} and Panhuysen, {Carolien I.M.} and Prenger, {Valerie L.} and Rebecca Koskela and Bart Kiemeney and LaBuda, {Michele C.} and Maestri, {Nancy E.} and Meyers, {Deborah A.}",

year = "1995",

doi = "10.1002/gepi.1370120649",

language = "English (US)",

volume = "12",

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TY - JOUR

T1 - Two‐locus approach of segregation and linkage analysis in the study of complex traits

AU - Xu, Jianfeng

AU - Taylor, Eugene W.

AU - Panhuysen, Carolien I.M.

AU - Prenger, Valerie L.

AU - Koskela, Rebecca

AU - Kiemeney, Bart

AU - LaBuda, Michele C.

AU - Maestri, Nancy E.

AU - Meyers, Deborah A.

PY - 1995

Y1 - 1995

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AB - A two‐locus segregation and linkage‐analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two‐locus Mendelian model fit the data significantly better than a one‐locus model. The linkage results based on the most parsimonious two‐locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one‐locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two‐locus models. © 1995 Wiley‐Liss, Inc.

KW - linkage analysis

KW - oligogenic model

KW - segregation analysis

KW - two‐locus

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Two‐locus approach of segregation and linkage analysis in the study of complex traits

Abstract

Keywords

ASJC Scopus subject areas

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