Two‐locus approach of segregation and linkage analysis in the study of complex traits

Jianfeng Xu, Eugene W. Taylor, Carolien I.M. Panhuysen, Valerie L. Prenger, Rebecca Koskela, Bart Kiemeney, Michele C. LaBuda, Nancy E. Maestri, Deborah A. Meyers

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A two‐locus segregation and linkage‐analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two‐locus Mendelian model fit the data significantly better than a one‐locus model. The linkage results based on the most parsimonious two‐locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one‐locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two‐locus models. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)825-830
Number of pages6
JournalGenetic Epidemiology
Issue number6
StatePublished - 1995
Externally publishedYes


  • linkage analysis
  • oligogenic model
  • segregation analysis
  • two‐locus

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)


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