Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes

Nicholas C. Dracopoli; Elise Rose; G. Kerr Whitfield; Peter T. Guidon; Sherri J. Bale; Phillip A. Chance; Ione A. Kourides; David E. Housman

doi:10.1016/0888-7543(88)90148-6

Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes

Nicholas C. Dracopoli, Elise Rose, G. Kerr Whitfield, Peter T. Guidon, Sherri J. Bale, Phillip A. Chance, Ione A. Kourides, David E. Housman

Basic Medical Sciences, Phoenix

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Abstract

Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (θ = 0.00, Z ̂ = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.

Original language	English (US)
Pages (from-to)	161-167
Number of pages	7
Journal	Genomics
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(88)90148-6
State	Published - Aug 1988

ASJC Scopus subject areas

Genetics

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Dracopoli, N. C., Rose, E., Whitfield, G. K., Guidon, P. T., Bale, S. J., Chance, P. A., Kourides, I. A., & Housman, D. E. (1988). Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes. Genomics, 3(2), 161-167. https://doi.org/10.1016/0888-7543(88)90148-6

Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes. / Dracopoli, Nicholas C.; Rose, Elise; Whitfield, G. Kerr et al.
In: Genomics, Vol. 3, No. 2, 08.1988, p. 161-167.

Research output: Contribution to journal › Article › peer-review

Dracopoli, NC, Rose, E, Whitfield, GK, Guidon, PT, Bale, SJ, Chance, PA, Kourides, IA & Housman, DE 1988, 'Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes', Genomics, vol. 3, no. 2, pp. 161-167. https://doi.org/10.1016/0888-7543(88)90148-6

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title = "Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes",

abstract = "Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (θ = 0.00, Z{\^ } = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.",

author = "Dracopoli, {Nicholas C.} and Elise Rose and Whitfield, {G. Kerr} and Guidon, {Peter T.} and Bale, {Sherri J.} and Chance, {Phillip A.} and Kourides, {Ione A.} and Housman, {David E.}",

note = "Funding Information: We thank Dr. A. Ullrich and Dr. G. Bell for providing probes. We are grateful to T. Bird for the use of two families for linkage analysis. This work was supported by PHS Grants CA-44176, CA-08748, CA-23185, and CA-40842.",

year = "1988",

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doi = "10.1016/0888-7543(88)90148-6",

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AU - Dracopoli, Nicholas C.

AU - Rose, Elise

AU - Whitfield, G. Kerr

AU - Guidon, Peter T.

AU - Bale, Sherri J.

AU - Chance, Phillip A.

AU - Kourides, Ione A.

AU - Housman, David E.

N1 - Funding Information: We thank Dr. A. Ullrich and Dr. G. Bell for providing probes. We are grateful to T. Bird for the use of two families for linkage analysis. This work was supported by PHS Grants CA-44176, CA-08748, CA-23185, and CA-40842.

PY - 1988/8

Y1 - 1988/8

N2 - Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (θ = 0.00, Z ̂ = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.

AB - Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1q22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (θ = 0.00, Z ̂ = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.

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Two thyroid hormone regulated genes, the β-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes

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