Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines

Zhigang Xu, Justin Dietrich, Arthur Y. Shaw, Christopher Hulme

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A two-step solution phase synthesis employing a double UDC (Ugi/Deprotect/Cyclize) strategy has been utilized to obtain fused 6,7,6,6-quinoxalinone-benzodiazepines and 6,7,7,6-bis-benzodiazepines. Optimization of the methodology to produce these tetracyclic scaffolds was enabled by microwave irradiation, incorporation of trifluoroethanol as solvent, and the use of the convertible isocyanide, 4-tert-butyl cyclohexen-1-yl isocyanide.

Original languageEnglish (US)
Pages (from-to)4566-4569
Number of pages4
JournalTetrahedron Letters
Issue number34
StatePublished - Aug 25 2010

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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