Two new improved approaches to the synthesis of coumarin-based prodrugs

Ailian Zheng, Wei Wang, Huijuan Zhang, Binghe Wang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Our laboratory has recently reported the development of a coumarin- based, esterase-sensitive prodrug system for the preparation of prodrugs of amines, peptides, and peptidomimetics. Biological evaluations including animal studies have demonstrated the clinical potential of this prodrug system. However, the original synthetic method used required a long sequence of reactions with a relatively low overall yield. In this report, we describe two new approaches to the synthesis of these coumarin-based prodrugs. The first approach is a photochemical approach taking advantage of the photoisomerization of cinnamic acid and its derivatives. The second approach is through the catalytic hydrogenation of a triple bond for the generation of the cis double bond in the coumarinic acid moiety. Both approaches allow for the synthesis of these prodrugs in fewer steps with much improved overall yield.

Original languageEnglish (US)
Pages (from-to)4237-4254
Number of pages18
Issue number14
StatePublished - Apr 1999
Externally publishedYes


  • Coumarin
  • Hydrogenation
  • Isomerization
  • Photochemistry

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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