@article{270a169f9f304905a0d5f4ba799c6c34,
title = "Two new cytotoxic cytochalasins from Xylaria obovata",
abstract = "Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylaria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.",
author = "Ermias Dagne and Gunatilaka, {A. A.Leslie} and Senait Asmellash and Dawit Abate and Kingston, {David G.I.} and Hofmann, {Glenn A.} and Johnson, {Randall K.}",
note = "Funding Information: This work wasf undedb y grantsf rom theN ationalC ancerI nstituteu ndera NationalC ooperativeD rug DiscoveryG roup awardedt o theU niversityo f Virginia (Dr. S. M. Hecht,P rincipal Investigator)f,r om the InternationalF oundation for Science (awardedt o D.A.), and from the Swedish Agency for Research Cooperationin DevelopingC ountries( awardedto E.D.). The visit of E.D. to V.P.I. & S.U. wass upportebdy a fellowshipo f theF ulbright-HaysF oundation.W e thankD r. T. Laessoe( Kew GardensL, ondon,U .K.) for identifyingt hef ungus;P rof. R. L. Edwards( Universityo f Bradford,U .K.) for a sampleo f cyclochalasinR ; Mr. T. Glass (V.P.I. & S.U.) for assistancien obtainings omeN MR spectraa; nd Mr. Kim Harich (V.P.I. & S.U.) andt heM idwestC enterf or MassS pectrometrwyi th partials upporbt y theN ationalS cienceF oundation BiologyD ivision (GrantN o. DIR 9017262f)o r MS.",
year = "1994",
doi = "10.1016/S0040-4020(01)85632-5",
language = "English (US)",
volume = "50",
pages = "5615--5620",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "19",
}