Two-component polyethylene glycol surgical sealant influence on intraperitoneal infection in a refined rodent model

Kathleen E. Rodgers, Florence G. Burleson, Gary R. Burleson, Martin J. Wolfsegger, Kevin M. Lewis, Heinz Redl

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: This study determined the influence of a 2-component polyethylene glycol surgical sealant (Coseal) as an adhesion prevention device on sepsis-related mortality and/or systemic bacterial translocation to the spleen. Study Design: A bacterial inoculum and telemetry probe were implanted in 50 treated and 49 untreated rats. Telemetry probes monitored core-body temperature to determine time of death. Spleens were collected on day 3 for quantitative bacteriology of Escherichia coli and Bacteroides fragilis. Results: Median survival time and mortality of treated rats (37.0 hours, 54.0%) were noninferior to untreated rats (47.5 hours, 55.1%). Median E coli titers in treated rats (2.24 log colony forming units/spleen) were significantly less than untreated rats (4.32 log colony forming units/spleen). B fragilis titers were not different. Conclusion: This study demonstrates intraperitoneal administration of a 2-component polyethylene glycol surgical sealant as an adhesion prevention device does not alter time to death or sepsis-related mortality and/or systemic bacterial translocation to the spleen.

Original languageEnglish (US)
Pages (from-to)494.e1-494.e6
JournalAmerican journal of obstetrics and gynecology
Volume203
Issue number5
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • adhesion barrier
  • animal model
  • Coseal
  • intraperitoneal infection
  • rodent model

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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