Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

Alexandra Friedrich; Cindy G. Arvidson; William M. Shafer; Eun Hee Lee; Magdalene So

doi:10.1128/JB.00300-07

Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

Alexandra Friedrich, Cindy G. Arvidson, William M. Shafer, Eun Hee Lee, Magdalene So

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

Original language	English (US)
Pages (from-to)	5399-5402
Number of pages	4
Journal	Journal of bacteriology
Volume	189
Issue number	14
DOIs	https://doi.org/10.1128/JB.00300-07
State	Published - Jul 2007

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/JB.00300-07

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abstract = "Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.",

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AU - Friedrich, Alexandra

AU - Arvidson, Cindy G.

AU - Shafer, William M.

AU - Lee, Eun Hee

AU - So, Magdalene

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AB - Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

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Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae

Abstract

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