Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Michelle Marks; Chad Steele; Wendy C. Moore; Deborah A. Meyers; Brian Rector; Elizabeth Ampleford; Eugene R. Bleecker; Annette T. Hastie

doi:10.1136/thoraxjnl-2019-214496

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Michelle Marks, Chad Steele, Wendy C. Moore, Deborah A. Meyers, Brian Rector, Elizabeth Ampleford, Eugene R. Bleecker, Annette T. Hastie

Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.

Original language	English (US)
Pages (from-to)	808-811
Number of pages	4
Journal	Thorax
Volume	75
Issue number	9
DOIs	https://doi.org/10.1136/thoraxjnl-2019-214496
State	Published - Sep 1 2020

Keywords

asthma mechanisms
cytokine biology

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2019-214496

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title = "Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study",

abstract = "Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.",

keywords = "asthma mechanisms, cytokine biology",

author = "Michelle Marks and Chad Steele and Moore, {Wendy C.} and Meyers, {Deborah A.} and Brian Rector and Elizabeth Ampleford and Bleecker, {Eugene R.} and Hastie, {Annette T.}",

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AU - Marks, Michelle

AU - Steele, Chad

AU - Moore, Wendy C.

AU - Meyers, Deborah A.

AU - Rector, Brian

AU - Ampleford, Elizabeth

AU - Bleecker, Eugene R.

AU - Hastie, Annette T.

N1 - Publisher Copyright: ©

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.

AB - Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.

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KW - cytokine biology

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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Abstract

Keywords

ASJC Scopus subject areas

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