TY - JOUR
T1 - Tumor-Induced Osteomalacia
T2 - Evidence of a Surgically Correctable Alteration in Vitamin D Metabolism
AU - Parker, Mitchell S.
AU - Mintz, Daniel H.
AU - Klein, Irwin
AU - Haussler, Mark R.
PY - 1981/2/6
Y1 - 1981/2/6
N2 - A 15-year-old boy was treated for nonfamilial hypophosphatemic rickets. Treatment with ergocalciferol, 100,000 units/day, and phosphorus, 2 to 4 g/day, failed to alleviate the rickets. Levels of 1α,25-dihydroxyvitamin D were low while levels of 25-hydroxyvitamin D were elevated. After removal of a benign fibroma, the level of 1α,25-dihydroxyvitamin D increased, the serum phosphorus level became normal, and the osteomalacia was cured. The alteration of vitamin D metabolism and associated hypophosphatemia in oncogenic osteomalacia is a potentially reversible cause of bone disease mediated by the tumor.
AB - A 15-year-old boy was treated for nonfamilial hypophosphatemic rickets. Treatment with ergocalciferol, 100,000 units/day, and phosphorus, 2 to 4 g/day, failed to alleviate the rickets. Levels of 1α,25-dihydroxyvitamin D were low while levels of 25-hydroxyvitamin D were elevated. After removal of a benign fibroma, the level of 1α,25-dihydroxyvitamin D increased, the serum phosphorus level became normal, and the osteomalacia was cured. The alteration of vitamin D metabolism and associated hypophosphatemia in oncogenic osteomalacia is a potentially reversible cause of bone disease mediated by the tumor.
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U2 - 10.1001/jama.1981.03310300046018
DO - 10.1001/jama.1981.03310300046018
M3 - Article
C2 - 7452873
AN - SCOPUS:0019873855
VL - 245
SP - 492
EP - 493
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 5
ER -