Tucson Children's Respiratory Study: 1980 to present

Lynn M. Taussig, Anne L. Wright, Catharine J. Holberg, Marilyn Halonen, Wayne J. Morgan, Fernando D. Martinez

Research output: Contribution to journalReview articlepeer-review

537 Scopus citations


The Tucson Children's Respiratory Study (TCRS), begun in 1980, has followed 1246 subjects from birth together with their family members to delineate the complex interrelationships between a large number of potential risk factors, acute lower respiratory tract illnesses, and chronic lung disorders later in childhood and early adult life, especially asthma. Nine hundred seventy-four (78%) of the original subjects are still being followed. Among its numerous findings, the TCRS has (1) described various wheezing disorders (transient, nonatopic, atopic) and their characteristics; (2) developed an Asthma Predictive Index; (3) delineated the respiratory and atopic outcomes for children who had respiratory syncytial virus-related wheezing illnesses in infancy; and (4) evaluated a large number of risk factors for acute respiratory tract illnesses during the first 3 years of life. Future TCRS studies will focus on (1) factors in infancy and early childhood that relate to persistent asthma and atopy; (2) role of genetic factors in persistent asthma; and (3) determinants of lung function decline in early adult life.

Original languageEnglish (US)
Pages (from-to)661-675
Number of pages15
JournalJournal of Allergy and Clinical Immunology
Issue number4
StatePublished - Apr 1 2003


  • Asthma
  • Atopy
  • Immunology
  • Lower respiratory tract illnesses
  • Lung function
  • Risk factors
  • Tucson Children's Respiratory Study
  • Wheezing syndromes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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