tsRNAs: The Swiss Army Knife for Translational Regulation

Junchao Shi; Yunfang Zhang; Tong Zhou; Qi Chen

doi:10.1016/j.tibs.2018.09.007

tsRNAs: The Swiss Army Knife for Translational Regulation

Junchao Shi, Yunfang Zhang, Tong Zhou, Qi Chen

Medicine

Research output: Contribution to journal › Short survey › peer-review

61 Scopus citations

Abstract

tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.tibs.2018.09.007
State	Published - Mar 2019

Keywords

RNA modification
RNA structure
ribosome
tRNA-derived small RNA
translational regulation

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2018.09.007

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title = "tsRNAs: The Swiss Army Knife for Translational Regulation",

abstract = "tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis.",

keywords = "RNA modification, RNA structure, ribosome, tRNA-derived small RNA, translational regulation",

author = "Junchao Shi and Yunfang Zhang and Tong Zhou and Qi Chen",

note = "Funding Information: Research in the Chen lab is supported by a grant from the NIH ( R01HD09243 ) Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = mar,

doi = "10.1016/j.tibs.2018.09.007",

language = "English (US)",

volume = "44",

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TY - JOUR

T1 - tsRNAs

T2 - The Swiss Army Knife for Translational Regulation

AU - Shi, Junchao

AU - Zhang, Yunfang

AU - Zhou, Tong

AU - Chen, Qi

PY - 2019/3

Y1 - 2019/3

N2 - tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis.

AB - tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis.

KW - RNA modification

KW - RNA structure

KW - ribosome

KW - tRNA-derived small RNA

KW - translational regulation

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DO - 10.1016/j.tibs.2018.09.007

M3 - Short survey

C2 - 30297206

AN - SCOPUS:85054514053

SN - 0968-0004

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SP - 185

EP - 189

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 3

ER -

tsRNAs: The Swiss Army Knife for Translational Regulation

Abstract

Keywords

ASJC Scopus subject areas

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