Abstract
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn 2± and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2165-2170 |
| Number of pages | 6 |
| Journal | Nano Letters |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 11 2012 |
| Externally published | Yes |
Keywords
- Polypeptides
- block copolymers
- pH responsive
- stimulus-responsive
- tumor drug delivery
ASJC Scopus subject areas
- Bioengineering
- General Chemistry
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering
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