Treatment parameters of desensitization to capsaicin

Rebecca M. Craft, Frank Porreca

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.

Original languageEnglish (US)
Pages (from-to)1767-1775
Number of pages9
JournalLife Sciences
Issue number23
StatePublished - 1992

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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