Treatment parameters of desensitization to capsaicin

Rebecca M. Craft; Frank Porreca

doi:10.1016/0024-3205(92)90046-R

Treatment parameters of desensitization to capsaicin

Rebecca M. Craft, Frank Porreca

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.

Original language	English (US)
Pages (from-to)	1767-1775
Number of pages	9
Journal	Life Sciences
Volume	51
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(92)90046-R
State	Published - 1992

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(92)90046-R

Cite this

@article{0a13a74df30b424d8f774e31afadb4dd,

title = "Treatment parameters of desensitization to capsaicin",

abstract = "Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.",

author = "Craft, {Rebecca M.} and Frank Porreca",

year = "1992",

doi = "10.1016/0024-3205(92)90046-R",

language = "English (US)",

volume = "51",

pages = "1767--1775",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "23",

}

TY - JOUR

T1 - Treatment parameters of desensitization to capsaicin

AU - Craft, Rebecca M.

AU - Porreca, Frank

PY - 1992

Y1 - 1992

N2 - Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.

AB - Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.

UR - http://www.scopus.com/inward/record.url?scp=0026446988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026446988&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(92)90046-R

DO - 10.1016/0024-3205(92)90046-R

M3 - Article

C2 - 1435085

AN - SCOPUS:0026446988

SN - 0024-3205

VL - 51

SP - 1767

EP - 1775

JO - Life Sciences

JF - Life Sciences

IS - 23

ER -

Treatment parameters of desensitization to capsaicin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this