Abstract
Biliary tract cancer (BTC) is a rare cancer with poor prognosis, characterized by considerable pathophysiological and molecular heterogeneity. While this makes it difficult to treat, it also provides targeted therapy opportunities. Current standard-of-care is chemotherapy ± immunotherapy, but several targeted agents have recently been approved. The current investigational landscape in BTC emphasizes the importance of biomarker testing at diagnosis. MDM2/MDMX are important negative regulators of the tumor suppressor p53 and provide an additional target in BTC (∼5–8% of tumors are MDM2-amplified). Brigimadlin (BI 907828) is a highly potent MDM2-p53 antagonist that has shown antitumor activity in preclinical studies and promising results in early clinical trials; enrollment is ongoing in a potential registrational trial for patients with BTC.
Original language | English (US) |
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Pages (from-to) | 1435-1450 |
Number of pages | 16 |
Journal | Future Oncology |
Volume | 20 |
Issue number | 20 |
DOIs | |
State | Published - 2024 |
Keywords
- BI 90782823
- MDM2–p53
- biliary tract cancer
- brigimadlin
- plain-language summary
- targeted therapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Treatment options for biliary tract cancer: unmet needs, new targets and opportunities from both physicians' and patients' perspectives
Shroff, R. T. (Creator) & Bachini, M. (Creator), Taylor & Francis, 2024
DOI: 10.6084/m9.figshare.26935920, https://tandf.figshare.com/articles/dataset/Treatment_options_for_biliary_tract_cancer_unmet_needs_new_targets_and_opportunities_from_both_physicians_and_patients_perspectives/26935920
Dataset
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Treatment options for biliary tract cancer: unmet needs, new targets and opportunities from both physicians' and patients' perspectives
Shroff, R. T. (Creator) & Bachini, M. (Creator), Taylor & Francis, 2024
DOI: 10.6084/m9.figshare.26935920.v1, https://tandf.figshare.com/articles/dataset/Treatment_options_for_biliary_tract_cancer_unmet_needs_new_targets_and_opportunities_from_both_physicians_and_patients_perspectives/26935920/1
Dataset