Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials

Michael X. Repka; Raymond T. Kraker; Roy W. Beck; Eileen Birch; Susan A. Cotter; Jonathan M. Holmes; Richard W. Hertle; Darren L. Hoover; Deborah L. Klimek; Wendy Marsh-Tootle; Mitchell M. Scheiman; Donny W. Suh; David R. Weakley

doi:10.1016/j.jaapos.2009.03.002

Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials

Michael X. Repka, Raymond T. Kraker, Roy W. Beck, Eileen Birch, Susan A. Cotter, Jonathan M. Holmes, Richard W. Hertle, Darren L. Hoover, Deborah L. Klimek, Wendy Marsh-Tootle, Mitchell M. Scheiman, Donny W. Suh, David R. Weakley

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.

Original language	English (US)
Pages (from-to)	258-263
Number of pages	6
Journal	Journal of AAPOS
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.jaapos.2009.03.002
State	Published - Jun 2009
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

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10.1016/j.jaapos.2009.03.002

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Repka, M. X., Kraker, R. T., Beck, R. W., Birch, E., Cotter, S. A., Holmes, J. M., Hertle, R. W., Hoover, D. L., Klimek, D. L., Marsh-Tootle, W., Scheiman, M. M., Suh, D. W., & Weakley, D. R. (2009). Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials. Journal of AAPOS, 13(3), 258-263. https://doi.org/10.1016/j.jaapos.2009.03.002

@article{558303dcdb0a4bf78f75fa4976f62a1b,

title = "Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials",

abstract = "Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.",

author = "Repka, {Michael X.} and Kraker, {Raymond T.} and Beck, {Roy W.} and Eileen Birch and Cotter, {Susan A.} and Holmes, {Jonathan M.} and Hertle, {Richard W.} and Hoover, {Darren L.} and Klimek, {Deborah L.} and Wendy Marsh-Tootle and Scheiman, {Mitchell M.} and Suh, {Donny W.} and Weakley, {David R.}",

note = "Funding Information: Supported by National Eye Institute of National Institutes of Health, Department of Health and Human Services (EY011751). ",

year = "2009",

month = jun,

doi = "10.1016/j.jaapos.2009.03.002",

language = "English (US)",

volume = "13",

pages = "258--263",

journal = "Journal of AAPOS",

issn = "1091-8531",

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T1 - Treatment of severe amblyopia with weekend atropine

T2 - Results from 2 randomized clinical trials

AU - Repka, Michael X.

AU - Kraker, Raymond T.

AU - Beck, Roy W.

AU - Birch, Eileen

AU - Cotter, Susan A.

AU - Holmes, Jonathan M.

AU - Hertle, Richard W.

AU - Hoover, Darren L.

AU - Klimek, Deborah L.

AU - Marsh-Tootle, Wendy

AU - Scheiman, Mitchell M.

AU - Suh, Donny W.

AU - Weakley, David R.

N1 - Funding Information: Supported by National Eye Institute of National Institutes of Health, Department of Health and Human Services (EY011751).

PY - 2009/6

Y1 - 2009/6

N2 - Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.

AB - Purpose: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. Methods: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. Results: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). Conclusions: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.{A figure is presented}.

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Treatment of severe amblyopia with weekend atropine: Results from 2 randomized clinical trials

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