Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial

A. N. Guthkelch; L. P. Carter; J. R. Cassady; K. H. Hynynen; R. P. Iacono; P. C. Johnson; E. A.M.T. Obbens; R. B. Roemer; J. F. Seeger; D. S. Shimm; B. Steal

doi:10.1007/BF00177540

Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial

A. N. Guthkelch, L. P. Carter, J. R. Cassady, K. H. Hynynen, R. P. Iacono, P. C. Johnson, E. A.M.T. Obbens, R. B. Roemer, J. F. Seeger, D. S. Shimm, B. Steal

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134 Scopus citations

Abstract

Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5°C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42°C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.

Original language	English (US)
Pages (from-to)	271-284
Number of pages	14
Journal	Journal of Neuro-Oncology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/BF00177540
State	Published - Jun 1991

Keywords

brain tumor oncology
glioblastoma multiforme
hyperthermia
radiation therapy
ultrasound

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/BF00177540

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Guthkelch, A. N., Carter, L. P., Cassady, J. R., Hynynen, K. H., Iacono, R. P., Johnson, P. C., Obbens, E. A. M. T., Roemer, R. B., Seeger, J. F., Shimm, D. S., & Steal, B. (1991). Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial. Journal of Neuro-Oncology, 10(3), 271-284. https://doi.org/10.1007/BF00177540

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title = "Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial",

abstract = "Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5°C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42°C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.",

keywords = "brain tumor oncology, glioblastoma multiforme, hyperthermia, radiation therapy, ultrasound",

author = "Guthkelch, {A. N.} and Carter, {L. P.} and Cassady, {J. R.} and Hynynen, {K. H.} and Iacono, {R. P.} and Johnson, {P. C.} and Obbens, {E. A.M.T.} and Roemer, {R. B.} and Seeger, {J. F.} and Shimm, {D. S.} and B. Steal",

year = "1991",

month = jun,

doi = "10.1007/BF00177540",

language = "English (US)",

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T2 - results of a phase I trial

AU - Guthkelch, A. N.

AU - Carter, L. P.

AU - Cassady, J. R.

AU - Hynynen, K. H.

AU - Iacono, R. P.

AU - Johnson, P. C.

AU - Obbens, E. A.M.T.

AU - Roemer, R. B.

AU - Seeger, J. F.

AU - Shimm, D. S.

AU - Steal, B.

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AB - Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5°C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42°C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.

KW - brain tumor oncology

KW - glioblastoma multiforme

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KW - radiation therapy

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Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial

Abstract

Keywords

ASJC Scopus subject areas

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