Treatment of hepatopulmonary syndrome with Allium sativum L. (Garlic): A pilot trial

Gary A. Abrams, Michael B. Fallon

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


No medical therapy exists for subjects with hepatopulmonary syndrome (HPS). A patient with HPS was reported to have improvement in arterial oxygenation while self-administering garlic. Our goal was to determine whether a standardized garlic powder improves arterial oxygenation and dyspnea in subjects with HPS. A prospective, open label uncontrolled pilot study in 15 subjects with HPS were administered garlic powder capsules daily for a minimum of 6 months. Arterial blood gases were determined every 4-8 weeks, in the same position on room air, and a subjective dyspnea transition index was reported. Six of 15 subjects (40%, confidence interval: 0.15-65) had at least a 10 mmHg increase in the P(O2) or decrease in the alveolar- arterial gradient. The mean pre- and postarterial difference in these patients were: P(O2) (14 ± 4 mmHg) and alveolar-arterial gradient (18 ± 5 mmHg). All 6 subjects who responded to garlic had less dyspnea on exertion. Garlic improved arterial oxygenation in younger subjects (mean 40 versus 56 years old; p = 0.021) or those with lower macroaggregated albumin shunt fractions (mean 21 versus 44%, p = 0.058). Garlic may improve arterial oxygenation and symptoms in patients with hepatopulmonary syndrome and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalJournal of clinical gastroenterology
Issue number3
StatePublished - Oct 1998


  • Garlic
  • Hepatopulmonary syndrome

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Treatment of hepatopulmonary syndrome with Allium sativum L. (Garlic): A pilot trial'. Together they form a unique fingerprint.

Cite this