Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine

Alan G. Palestine; Garth Stevens; H. Clifford Lane; Henry Masur; Leslie S. Fujikawa; Robert B. Nussenblatt; Alain H. Rook; Jody Manischewitz; Barbara Baird; Margaret Megill; Gerald Quinnan; Edward Gelmann; Anthony S. Fauci

doi:10.1016/0002-9394(86)90470-8

Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine

Alan G. Palestine, Garth Stevens, H. Clifford Lane, Henry Masur, Leslie S. Fujikawa, Robert B. Nussenblatt, Alain H. Rook, Jody Manischewitz, Barbara Baird, Margaret Megill, Gerald Quinnan, Edward Gelmann, Anthony S. Fauci

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Abstract

Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.

Original language	English (US)
Pages (from-to)	95-101
Number of pages	7
Journal	American Journal of Ophthalmology
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/0002-9394(86)90470-8
State	Published - Jan 15 1986
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/0002-9394(86)90470-8

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Palestine, A. G., Stevens, G., Clifford Lane, H., Masur, H., Fujikawa, L. S., Nussenblatt, R. B., Rook, A. H., Manischewitz, J., Baird, B., Megill, M., Quinnan, G., Gelmann, E., & Fauci, A. S. (1986). Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine. American Journal of Ophthalmology, 101(1), 95-101. https://doi.org/10.1016/0002-9394(86)90470-8

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title = "Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine",

abstract = "Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.",

author = "Palestine, {Alan G.} and Garth Stevens and {Clifford Lane}, H. and Henry Masur and Fujikawa, {Leslie S.} and Nussenblatt, {Robert B.} and Rook, {Alain H.} and Jody Manischewitz and Barbara Baird and Margaret Megill and Gerald Quinnan and Edward Gelmann and Fauci, {Anthony S.}",

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AU - Palestine, Alan G.

AU - Stevens, Garth

AU - Clifford Lane, H.

AU - Masur, Henry

AU - Fujikawa, Leslie S.

AU - Nussenblatt, Robert B.

AU - Rook, Alain H.

AU - Manischewitz, Jody

AU - Baird, Barbara

AU - Megill, Margaret

AU - Quinnan, Gerald

AU - Gelmann, Edward

AU - Fauci, Anthony S.

PY - 1986/1/15

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N2 - Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.

AB - Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.

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Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine

Abstract

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