Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine

Alan G. Palestine, Garth Stevens, H. Clifford Lane, Henry Masur, Leslie S. Fujikawa, Robert B. Nussenblatt, Alain H. Rook, Jody Manischewitz, Barbara Baird, Margaret Megill, Gerald Quinnan, Edward Gelmann, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume101
Issue number1
DOIs
StatePublished - Jan 15 1986
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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