TY - JOUR
T1 - Treatment of Bilateral Refractive Amblyopia in Children Three to Less Than 10 Years of Age
AU - Wallace, David K.
AU - Chandler, Danielle L.
AU - Beck, Roy W.
AU - Arnold, Robert W.
AU - Bacal, Darron A.
AU - Birch, Eileen E.
AU - Felius, Joost
AU - Frazier, Marcela
AU - Holmes, Jonathan M.
AU - Hoover, Darren
AU - Klimek, Deborah A.
AU - Lorenzana, Ingryd
AU - Quinn, Graham E.
AU - Repka, Michael X.
AU - Suh, Donny W.
AU - Tamkins, Susanna
N1 - Funding Information:
This study was supported by grant EY11751 from the National Eye Institute, Bethesda, Maryland. The authors indicate no financial conflict of interest. Involved in design of study (D.W., D.C., R.B., R.A., E.B., J.F., J.H., D.K., G.Q., M.R., S.T.); all of the authors were involved in the collection, management, analysis, and interpretation of the data and the preparation, review, and final approval of the manuscript. The respective institutional review boards approved the protocol and Health Insurance Portability and Accountability Act-compliant informed consent forms.
Funding Information:
Center received support utilized for this project from an unrestricted grant from Research to Prevent Blindness Inc, New York, New York.
PY - 2007/10
Y1 - 2007/10
N2 - Purpose: To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age. Design: Prospective, multicenter, noncomparative intervention. Methods: One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year. Results: Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks. Conclusions: Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.
AB - Purpose: To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age. Design: Prospective, multicenter, noncomparative intervention. Methods: One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year. Results: Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks. Conclusions: Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.
UR - https://www.scopus.com/pages/publications/34548767761
UR - https://www.scopus.com/pages/publications/34548767761#tab=citedBy
U2 - 10.1016/j.ajo.2007.05.040
DO - 10.1016/j.ajo.2007.05.040
M3 - Article
C2 - 17707330
AN - SCOPUS:34548767761
SN - 0002-9394
VL - 144
SP - 487
EP - 496
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -