Treatment of Acute Intravascular Thrombi With Diagnostic Ultrasound and Intravenous Microbubbles

Feng Xie, John Lof, Carr Everbach, Anming He, Richard M. Bennett, Terry Matsunaga, Jason Johanning, Thomas R. Porter

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


The purpose of this study was to determine whether high mechanical index (MI) impulses from diagnostic ultrasound (DUS) could dissolve intravascular thrombi using intravenous microbubbles. Using a canine model, DUS was applied during a continuous intravenous infusion of microbubbles. Completely thrombosed grafts were assigned to 2 treatment regimens: low-MI (<0.5-MI) ultrasound alone; or intermittent high-MI impulses (1.9-MI) guided by low-MI ultrasound (contrast pulse sequencing). A 20-MHz cavitation detector was placed confocal to the ultrasound transducer to make intravascular cavitation measurements in 1 dog. Intravascular cavitational activity was detected when an MI of >0.5 was applied. In grafts treated with intermittent high-MI ultrasound, angiographic success was 71% at 30 min and 79% at 45 min, compared with 20% and 30% at these times in the low-MI ultrasound alone group (p < 0.05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalJACC: Cardiovascular Imaging
Issue number4
StatePublished - Apr 2009


  • cavitation
  • microbubbles
  • thrombolysis
  • ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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