Clinical orthotopic liver transplantation - removal of the entire liver and its replacement with a homograft - was first performed on March 1, 1963 at the University of Colorado. During the next 13 years, approximately 265 such procedures have been performed throughout the world. The University of Colorado series now numbers 113 patients, or about 40 per cent of the total experience. In a recent extensive review, our first 93 cases were analyzed in detail, emphasizing clinical and pathologic correlations.4 In this article, we will focus upon certain areas of our experience; our results with this procedure, our present views regarding candidacy for liver replacement, and finally, selected diagnostic and technical problems that are encountered during and after liver transplantation, particularly the problem of secondary jaundice.
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