Transplantation autoimmunity: The rediscovery of self

Eugenia V. Fedoseyeva, Monika Zwierzchoniewska, Robert C. Robbins

Research output: Contribution to journalReview articlepeer-review


Novel observations in the field highlight the importance of the early innate response to ischemia/reperfusion (I/R) injury and the contribution of host immunologic memory in determining the graft outcome. Further research in this direction may lead to identification of common regulatory check-points that shape the host anti-graft response, and thus may potentiate development of feasible and cost-effective therapies. Better understanding of the different pathways of anti-graft immunity may help to identify the genetic basis of pathologic immune reactions in transplant patients.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Issue number1
StatePublished - Mar 2005
Externally publishedYes


  • Autoimmunity
  • Chronic rejection
  • Graft coronary artery disease
  • Ischemia
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation


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