Abstract
Novel observations in the field highlight the importance of the early innate response to ischemia/reperfusion (I/R) injury and the contribution of host immunologic memory in determining the graft outcome. Further research in this direction may lead to identification of common regulatory check-points that shape the host anti-graft response, and thus may potentiate development of feasible and cost-effective therapies. Better understanding of the different pathways of anti-graft immunity may help to identify the genetic basis of pathologic immune reactions in transplant patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9-14 |
| Number of pages | 6 |
| Journal | Current Opinion in Organ Transplantation |
| Volume | 10 |
| Issue number | 1 |
| State | Published - Mar 2005 |
| Externally published | Yes |
Keywords
- Autoimmunity
- Chronic rejection
- Graft coronary artery disease
- Ischemia
- Transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation