Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

Yuan Liu, Yang Yu, Yiwei Fu, Yonghai Liu, Lei Shi, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible "one-pot" tandem reaction to afford the annulation products in moderate to good yields.

Original languageEnglish (US)
Pages (from-to)2119-2123
Number of pages5
JournalOrganic Chemistry Frontiers
Volume4
Issue number11
DOIs
StatePublished - Nov 2017
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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