Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

Yuan Liu; Yang Yu; Yiwei Fu; Yonghai Liu; Lei Shi; Hao Li; Wei Wang

doi:10.1039/c7qo00529f

Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

Yuan Liu, Yang Yu, Yiwei Fu, Yonghai Liu, Lei Shi, Hao Li, Wei Wang

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible "one-pot" tandem reaction to afford the annulation products in moderate to good yields.

Original language	English (US)
Pages (from-to)	2119-2123
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	4
Issue number	11
DOIs	https://doi.org/10.1039/c7qo00529f
State	Published - Nov 2017
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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abstract = "A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible {"}one-pot{"} tandem reaction to afford the annulation products in moderate to good yields.",

author = "Yuan Liu and Yang Yu and Yiwei Fu and Yonghai Liu and Lei Shi and Hao Li and Wei Wang",

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AU - Liu, Yuan

AU - Yu, Yang

AU - Fu, Yiwei

AU - Liu, Yonghai

AU - Shi, Lei

AU - Li, Hao

AU - Wang, Wei

PY - 2017/11

Y1 - 2017/11

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AB - A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible "one-pot" tandem reaction to afford the annulation products in moderate to good yields.

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Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

Abstract

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