Transient Inhibition of Translation Improves Cardiac Function after Ischemia/Reperfusion by Attenuating the Inflammatory Response

Keyphrases

• Cardiac Function 100%
• Reperfusion 100%
• Inflammatory Response 100%
• Translation Inhibition 100%
• Ischemia-reperfusion 100%
• Mammalian Target of Rapamycin (mTOR) 66%
• Monocyte Infiltration 66%
• MRNA Translation 66%
• 4E-BP1 50%
• Protein Synthesis 50%
• Translation Initiation 50%
• Cardiomyocytes 50%
• Cross-border Region 50%
• Myocardium 33%
• Gene Expression 33%
• Inflammation 33%
• Ribosome Profiling 33%
• Circulating Monocytes 33%
• Ly6Chi Monocytes 33%
• Infarct Zone 33%
• Gene Regulation 16%
• Inflammatory Cytokines 16%
• Ischemia 16%
• Infarct Size 16%
• Myocardial Infarction 16%
• Pharmacological Inhibitors 16%
• Translational Control 16%
• Ischemia-reperfusion Injury 16%
• Changes in Gene Expression 16%
• Cardiac Gene Expression 16%
• Injury Levels 16%
• Eukaryotic Initiation Factor 16%
• Rapamycin 16%
• Type-specific 16%
• Inflammatory Gene Expression 16%
• Translation Inhibitor 16%
• Complex Formation 16%
• Cell Infiltration 16%
• Cardiac Cells 16%
• Immunomodulatory Effect 16%
• Translational Regulation 16%
• Inflammation Regulation 16%
• Pharmacological Targeting 16%
• Rapid Recovery 16%
• Cardiac Response 16%
• Cardiac Inflammation 16%
• 4EGI-1 16%
• Translational Activity 16%
• Myocardial Inflammation 16%
• Genetic Targeting 16%
• Immune Cell Infiltration 16%
• Chemokine Ligand 2 (CCL2) 16%

Immunology and Microbiology

• Heart Function 100%
• Inflammation Response 100%
• Reperfusion 100%
• Gene Expression 50%
• Monocyte 50%
• Initiation Factor 4F 50%
• Mammalian Target of Rapamycin Complex 1 33%
• RNA Translation 33%
• Inflammation 33%
• Cardiac Muscle Cell 25%
• Translation Initiation 25%
• Protein Synthesis 25%
• Proinflammatory Cytokine 8%
• Protein Binding 8%
• Sirolimus 8%
• Complex Formation 8%
• Immunosuppressive Drug 8%
• Chemokine 8%
• Myocarditis 8%
• Cell Infiltration 8%
• Initiation Factor 4E 8%
• Immune Cell Infiltration 8%
• In Vitro 8%

Biochemistry, Genetics and Molecular Biology

• Heart Function 100%
• Reperfusion 100%
• Gene Expression 50%
• Monocyte 50%
• RNA Translation 33%
• Mammalian Target of Rapamycin Complex 1 33%
• Protein Biosynthesis 25%
• Cardiac Muscle Cell 25%
• Translation Initiation 25%
• Cell Infiltration 16%
• Messenger RNA 16%
• Binding Protein 8%
• Genetics 8%
• Complex Formation 8%
• Eukaryotic Initiation Factor 8%
• Immunocompetent Cell 8%
• Synapsin I 8%
• Proinflammatory Cytokine 8%
• Chemokine 8%
• Translational Regulation 8%