Transforming growth factor‐β1 in reproduction

Marcia M. Shull, Thomas Doetschman

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Expression patterns of TGF‐βs during embryogenesis and in adult reproductive organs, as well as the activities of these molecules in in vitro assays of biological processes relating to reproduction and development, have suggested that TGF‐βs may play a role in both reproductive function and embryonic development. To investigate the function of TGF‐β1 in vivo, the murine TGF‐β1 gene was disrupted by gene targeting, and animals that lacked TGF‐β1 activity were generated. Homozygous mutant animals were obtained which exhibited a multifocal inflammatory disease. However, the observed numbers of homozygous mutant offspring were less than expected, suggesting the occurrence of some type of prenatal lethality. This paper reviews the proposed role of the TGF‐βs in reproductive and developmental processes and discusses observations obtained from the TGF‐β1 gene‐targeting experiments as they relate to these processes. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalMolecular Reproduction and Development
Issue number2
StatePublished - Oct 1994


  • Embryogenesis
  • Implantation
  • Ovary
  • Placenta
  • Testis
  • Uterus

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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