Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells

Tyler J. Ripperger, Deepta Bhattacharya

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the primary basis and best functional correlate of immunological protection. Durable long-term humoral immunity is mediated by antibodies secreted by plasma cells that preexist subsequent exposures and by memory B cells that rapidly respond to infections once they have occurred. In the midst of the current pandemic of coronavirus disease 2019, it is important to define our current understanding of the unique roles of memory B cells and plasma cells in immunity and the factors that control the formation and persistence of these cell types. This fundamental knowledge is the basis to interpret findings from natural infections and vaccines. Here, we review transcriptional and metabolic programs that promote and support B cell fates and functions, suggesting points at which these pathways do and do not intersect.

Original languageEnglish (US)
Pages (from-to)345-368
Number of pages24
JournalAnnual review of immunology
StatePublished - Apr 26 2021


  • germinal centers
  • memory B cells
  • metabolism
  • plasma cells
  • transcription

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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