Tranilast: A pharmaceutical candidate for reduction of adhesions using a novel approach

Janel Petrilli, Scott Wadsworth, Kevin Cooper, Kathleen E. Rodgers, John Siekierka, Gere S. DiZerega

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Postsurgical adhesion formation has numerous deleterious side effects in a wide variety of surgical settings. Physical barriers used together with laparoscopy were developed in hopes of reducing the tissue trauma seen with open procedures and separating tissues during the critical time of healing to reduce adhesion formation. Despite meticulous techniques by surgeons and the availability of barriers, adhesion formation remains a serious problem, with more than $1 billion spent annually on complications arising from adhesions. Our laboratories have combined a previously marketed drug, Tranilast, with a gel to provide a locally delivered medicated device that can reduce adhesion formation. This article will review the role of Tranilast in the key pathways involved in adhesion formation.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalSeminars in Reproductive Medicine
Volume26
Issue number4
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • Adhesions
  • Gynecologic surgery
  • Mast cells
  • Surgery
  • Transilast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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