Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

Francesc Castro-Giner; Nino Künzli; Bénédicte Jacquemin; Bertil Forsberg; Rafael De Cid; Jordi Sunyer; Deborah Jarvis; David Briggs; Danielle Vienneau; Dan Norback; Juan R. González; Stefano Guerra; Christer Janson; Josep Maria Antó; Matthias Wjst; Joachim Heinrich; Xavier Estivill; Manolis Kogevinas

doi:10.1289/ehp.0900589

Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

Francesc Castro-Giner, Nino Künzli, Bénédicte Jacquemin, Bertil Forsberg, Rafael De Cid, Jordi Sunyer, Deborah Jarvis, David Briggs, Danielle Vienneau, Dan Norback, Juan R. González, Stefano Guerra, Christer Janson, Josep Maria Antó, Matthias Wjst, Joachim Heinrich, Xavier Estivill, Manolis Kogevinas

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO₂ estimates were available. Home addresses were geocoded and linked to modeled outdoor NO₂ estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO ₂ and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO₂ was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO2 for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.

Original language	English (US)
Pages (from-to)	1919-1924
Number of pages	6
Journal	Environmental health perspectives
Volume	117
Issue number	12
DOIs	https://doi.org/10.1289/ehp.0900589
State	Published - Dec 2009
Externally published	Yes

Keywords

Air pollution
Asthma
Gene polymorphisms
Genetics
Nitrogen dioxide
Oxidative stress
Traffic pollution

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1289/ehp.0900589

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Castro-Giner, F., Künzli, N., Jacquemin, B., Forsberg, B., De Cid, R., Sunyer, J., Jarvis, D., Briggs, D., Vienneau, D., Norback, D., González, J. R., Guerra, S., Janson, C., Antó, J. M., Wjst, M., Heinrich, J., Estivill, X., & Kogevinas, M. (2009). Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS). Environmental health perspectives, 117(12), 1919-1924. https://doi.org/10.1289/ehp.0900589

Castro-Giner, F, Künzli, N, Jacquemin, B, Forsberg, B, De Cid, R, Sunyer, J, Jarvis, D, Briggs, D, Vienneau, D, Norback, D, González, JR, Guerra, S, Janson, C, Antó, JM, Wjst, M, Heinrich, J, Estivill, X & Kogevinas, M 2009, 'Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)', Environmental health perspectives, vol. 117, no. 12, pp. 1919-1924. https://doi.org/10.1289/ehp.0900589

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title = "Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)",

abstract = "BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO2 estimates were available. Home addresses were geocoded and linked to modeled outdoor NO2 estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO 2 and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO2 was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO2 for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.",

keywords = "Air pollution, Asthma, Gene polymorphisms, Genetics, Nitrogen dioxide, Oxidative stress, Traffic pollution",

author = "Francesc Castro-Giner and Nino K{\"u}nzli and B{\'e}n{\'e}dicte Jacquemin and Bertil Forsberg and {De Cid}, Rafael and Jordi Sunyer and Deborah Jarvis and David Briggs and Danielle Vienneau and Dan Norback and Gonz{\'a}lez, {Juan R.} and Stefano Guerra and Christer Janson and Ant{\'o}, {Josep Maria} and Matthias Wjst and Joachim Heinrich and Xavier Estivill and Manolis Kogevinas",

year = "2009",

month = dec,

doi = "10.1289/ehp.0900589",

language = "English (US)",

volume = "117",

pages = "1919--1924",

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AU - Castro-Giner, Francesc

AU - Künzli, Nino

AU - Jacquemin, Bénédicte

AU - Forsberg, Bertil

AU - De Cid, Rafael

AU - Sunyer, Jordi

AU - Jarvis, Deborah

AU - Briggs, David

AU - Vienneau, Danielle

AU - Norback, Dan

AU - González, Juan R.

AU - Guerra, Stefano

AU - Janson, Christer

AU - Antó, Josep Maria

AU - Wjst, Matthias

AU - Heinrich, Joachim

AU - Estivill, Xavier

AU - Kogevinas, Manolis

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO2 estimates were available. Home addresses were geocoded and linked to modeled outdoor NO2 estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO 2 and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO2 was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO2 for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.

AB - BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO2 estimates were available. Home addresses were geocoded and linked to modeled outdoor NO2 estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO 2 and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO2 was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO2 for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.

KW - Air pollution

KW - Asthma

KW - Gene polymorphisms

KW - Genetics

KW - Nitrogen dioxide

KW - Oxidative stress

KW - Traffic pollution

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Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

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