Traffic jams: Protein transport in Plasmodium falciparum

G. G. Van Dooren, R. F. Waller, G. I. McFadden, K. A. Joiner, D. S. Roos

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Protein targeting in malaria parasites is a complex process, involving several cellular compartments that distinguish these cells from more familiar systems, such as yeast or mammals. At least a dozen distinct protein destinations are known. The best studied of these is the vestigial chloroplast (the apicoplast), but new tools promise rapid progress in understanding how Plasmodium falciparum and related apicomplexan parasites traffic proteins to their invasion-related organelles, and how they modify the host by trafficking proteins into its cytoplasm and plasma membrane. Here, Giel van Dooren and colleagues discuss recent insights into protein targeting via the secretory pathway in this fascinating and important system. This topic emerged as a major theme at the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)421-427
Number of pages7
JournalParasitology Today
Issue number10
StatePublished - Oct 1 2000

ASJC Scopus subject areas

  • Parasitology


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