Toxicokinetics and Toxicodynamics of Anti-infective Agents

Research output: Chapter in Book/Report/Conference proceedingChapter


Toxicokinetics (TK) is an essential component of preclinical toxicology assessment. The primary objective is to characterize systemic exposure (blood, plasma, or serum) to add relevance to toxicological findings. Parameters such as Cmax and AUC allow comparison of exposures between species and different studies to clarify the relationship between toxic effects and dosimetr y. Further information can be gained by considering toxicodynamics (TD) in conjunction with TK, and results can be summarized descriptively or with a model-based strategy. This chapter provides a description of TK/TD and provides examples of the application of TK/TD principles in the development of anti-infective agents.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Number of pages15
StatePublished - 2016

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053


  • Anti-infectives
  • Drug development
  • Preclinical toxicology
  • TK/TD
  • Toxicodynamics
  • Toxicokinetics

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • Molecular Medicine


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