Toxic Shock‐Like Syndrome

Brian L. Erstad, Charles L. Witte, Deborah F. Talkington

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Invasive group A streptococcal infection has important diagnostic and therapeutic implications in patients with necrotizing fasciitis. We cared for a man with the full‐blown syndrome in whom many features of toxic shock syndrome were present, including profound hypotension and renal failure. The diagnostic similarities of toxic shock syndrome and the toxic shock‐like syndrome caused by group A Streptococcus could have led to inappropriate treatment. Successful therapy in our patient included high doses initially of broad‐spectrum antibiotics, repeated operative debridement of the lower leg (the affected limb), and ultimately, reconstructive surgery consisting primarily of split‐thickness skin grafts. The reemergence of invasive streptococcal infections may relate to changes either in virulence factors of the causative streptococcus or in exotoxins elaborated by this microorganism. A causative relationship between an exotoxin produced by group A Streptococcus and the toxic shock‐like syndrome has not yet been established. 1992 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number1
StatePublished - 1992

ASJC Scopus subject areas

  • Pharmacology (medical)


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