@inproceedings{3756daaaf6d841d99672c74e39585e3e,
title = "Towards a multiphysics model for tumor response to combined-hyperthermia-radiotherapy treatment",
abstract = "We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within the tumor microenvironment. This leads to radiosensitization, which improves the performance of radiotherapy while reducing the side-effects of excess radiation in the surrounding normal tissue. Existing tools to model this kind of treatment consider each of the physics separately. The model presented in this paper accounts for the synergy between hyperthermia and radiotherapy providing a more realistic and holistic approach to simulate CHR treatment. Our model couples radiation transport and heat-transfer with cell population dynamics.",
keywords = "Hyperthermia, Multiphysics, Radiotherapy, Transport, Tumor dynamics",
author = "Patel, {Japan K.} and Richard Vasques and Ganapol, {Barry D.}",
note = "Funding Information: J. K. Patel and R. Vasques acknowledge support under award number NRC-HQ-84-15-G-0024 from the Nuclear Regulatory Commission. The statements, findings, conclusions, and recommendations are those of the authors and do not necessarily reflect the view of the U.S. Nuclear Regulatory Commission. Publisher Copyright: {\textcopyright} 2019 American Nuclear Society. All rights reserved.; 2019 International Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019 ; Conference date: 25-08-2019 Through 29-08-2019",
year = "2019",
language = "English (US)",
series = "International Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019",
publisher = "American Nuclear Society",
pages = "1002--1011",
booktitle = "International Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019",
}