Toward the development of miniaturized imaging systems for detection of pre-cancer

Michael R. Descour; Ari H.O. Kärkkäinen; Jeremy D. Rogers; Chen Liang; Ronald S. Weinstein; Juha T. Rantala; Bahattin Kilic; Erdogan Madenci; Rebecca R. Richards-Kortum; Eric V. Anslyn; Russell D. Dupuis; Randy J. Schul; Christi G. Willison; Chris P. Tigges

doi:10.1109/3.980264

Toward the development of miniaturized imaging systems for detection of pre-cancer

Michael R. Descour, Ari H.O. Kärkkäinen, Jeremy D. Rogers, Chen Liang, Ronald S. Weinstein, Juha T. Rantala, Bahattin Kilic, Erdogan Madenci, Rebecca R. Richards-Kortum, Eric V. Anslyn, Russell D. Dupuis, Randy J. Schul, Christi G. Willison, Chris P. Tigges

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

Original language	English (US)
Pages (from-to)	122-130
Number of pages	9
Journal	IEEE Journal of Quantum Electronics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1109/3.980264
State	Published - Feb 2002

Keywords

Biomedical imaging
Biomedical microscopy
Hybrid sol-gel materials
Microassembly
Microoptics
Photolithography

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Electrical and Electronic Engineering

Access to Document

10.1109/3.980264

Cite this

Descour, M. R., Kärkkäinen, A. H. O., Rogers, J. D., Liang, C., Weinstein, R. S., Rantala, J. T., Kilic, B., Madenci, E., Richards-Kortum, R. R., Anslyn, E. V., Dupuis, R. D., Schul, R. J., Willison, C. G., & Tigges, C. P. (2002). Toward the development of miniaturized imaging systems for detection of pre-cancer. IEEE Journal of Quantum Electronics, 38(2), 122-130. https://doi.org/10.1109/3.980264

Descour, MR, Kärkkäinen, AHO, Rogers, JD, Liang, C, Weinstein, RS, Rantala, JT, Kilic, B, Madenci, E, Richards-Kortum, RR, Anslyn, EV, Dupuis, RD, Schul, RJ, Willison, CG & Tigges, CP 2002, 'Toward the development of miniaturized imaging systems for detection of pre-cancer', IEEE Journal of Quantum Electronics, vol. 38, no. 2, pp. 122-130. https://doi.org/10.1109/3.980264

@article{96387320d91c4e6fa684aaa072b98c92,

title = "Toward the development of miniaturized imaging systems for detection of pre-cancer",

abstract = "In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.",

keywords = "Biomedical imaging, Biomedical microscopy, Hybrid sol-gel materials, Microassembly, Microoptics, Photolithography",

author = "Descour, {Michael R.} and K{\"a}rkk{\"a}inen, {Ari H.O.} and Rogers, {Jeremy D.} and Chen Liang and Weinstein, {Ronald S.} and Rantala, {Juha T.} and Bahattin Kilic and Erdogan Madenci and Richards-Kortum, {Rebecca R.} and Anslyn, {Eric V.} and Dupuis, {Russell D.} and Schul, {Randy J.} and Willison, {Christi G.} and Tigges, {Chris P.}",

note = "Funding Information: Manuscript received June 6, 2001 This work was supported by the National Science Foundation (NSF) (BES-0086736) and by NSF SGER ECS-0074578. The work of A. H. O. K{\"a}rkk{\"a}inen was supported by VTT Electronics, Oulu, Finland. Funding Information: The authors gratefully acknowledge the support of Veeco Metrology (www.wyko.com), Tucson, AZ, and Wavefront Sciences, Inc. (www.wavefrontsciences.com), Albuquerque, NM. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000.",

year = "2002",

month = feb,

doi = "10.1109/3.980264",

language = "English (US)",

volume = "38",

pages = "122--130",

journal = "IEEE Journal of Quantum Electronics",

issn = "0018-9197",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "2",

}

TY - JOUR

T1 - Toward the development of miniaturized imaging systems for detection of pre-cancer

AU - Descour, Michael R.

AU - Kärkkäinen, Ari H.O.

AU - Rogers, Jeremy D.

AU - Liang, Chen

AU - Weinstein, Ronald S.

AU - Rantala, Juha T.

AU - Kilic, Bahattin

AU - Madenci, Erdogan

AU - Richards-Kortum, Rebecca R.

AU - Anslyn, Eric V.

AU - Dupuis, Russell D.

AU - Schul, Randy J.

AU - Willison, Christi G.

AU - Tigges, Chris P.

N1 - Funding Information: Manuscript received June 6, 2001 This work was supported by the National Science Foundation (NSF) (BES-0086736) and by NSF SGER ECS-0074578. The work of A. H. O. Kärkkäinen was supported by VTT Electronics, Oulu, Finland. Funding Information: The authors gratefully acknowledge the support of Veeco Metrology (www.wyko.com), Tucson, AZ, and Wavefront Sciences, Inc. (www.wavefrontsciences.com), Albuquerque, NM. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000.

PY - 2002/2

Y1 - 2002/2

N2 - In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

AB - In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

KW - Biomedical imaging

KW - Biomedical microscopy

KW - Hybrid sol-gel materials

KW - Microassembly

KW - Microoptics

KW - Photolithography

UR - http://www.scopus.com/inward/record.url?scp=0036477308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036477308&partnerID=8YFLogxK

U2 - 10.1109/3.980264

DO - 10.1109/3.980264

M3 - Article

AN - SCOPUS:0036477308

SN - 0018-9197

VL - 38

SP - 122

EP - 130

JO - IEEE Journal of Quantum Electronics

JF - IEEE Journal of Quantum Electronics

IS - 2

ER -

Toward the development of miniaturized imaging systems for detection of pre-cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this