@article{5e37d1418b06416ab03ce9c455472911,
title = "Total Synthesis of (±)-Phomoidride D",
abstract = "Described herein is a synthetic strategy for the total synthesis of (±)-phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels–Alder cycloaddition. A subsequent SmI2-mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion.",
keywords = "bicyclic compounds, cycloaddition, natural products, oxidation, total synthesis",
author = "Leung, {Joyce C.} and Bedermann, {Aaron A.} and Njardarson, {J{\'o}n T.} and Spiegel, {David A.} and Murphy, {Graham K.} and Naoto Hama and Twenter, {Barry M.} and Ping Dong and Tatsuya Shirahata and McDonald, {Ivar M.} and Munenori Inoue and Nobuaki Taniguchi and McMahon, {Travis C.} and Schneider, {Christopher M.} and Nancy Tao and Stoltz, {Brian M.} and Wood, {John L.}",
note = "Funding Information: The authors gratefully acknowledge support of this work from Bristol-Myers Squibb, Eli Lilly, Glaxo-Wellcome, Yamanou-chi (now Astellas), AstraZeneca, and Amgen through their faculty award programs, and the Camille and Henry Dreyfus Foundation for a Teacher Scholar Award to J.W. J.T.N. thanks the Helgu and J{\'o}nsd{\'o}ttur and SigurliMa Kristj#nsson Memorial Foundation, G.K.M. thanks the NSERC of Canada, T.S. thanks Prof. Satoshi O¯mura and the Kitasato Institute, and N.T. thanks Yamanouchi (now Astellas). The authors thank Prof. Kevin Klausmeyer and Ms. Sam Yruegas for obtaining and analyzing X-ray crystallographic data. We also gratefully acknowledge financial support from Baylor University, the Welch Foundation (Chair, AA-006), and the Cancer Prevention and Research Institute of Texas (CPRIT, R1309). Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = feb,
day = "12",
doi = "10.1002/anie.201712369",
language = "English (US)",
volume = "57",
pages = "1991--1994",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "7",
}