Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience

Gorjana Radisic; Colleen Etherton; Alice Rickard; Merle Weetra; Denghao Wu; Sanjeev Khurana; Bhanu Mariyappa; Jenny Harrington; Tom Loudovaris; Gordon Thomas; Henry C.C. Pleass; Alex Brown; Thomas W. Kay; Christopher J. Drogemuller; David J. Torpy; Richard Couper; John Chen; Patrick T. Coates

doi:10.5694/mja2.70129

Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience

Gorjana Radisic
, Colleen Etherton
, Alice Rickard
, Merle Weetra
, Denghao Wu
, Sanjeev Khurana
, Bhanu Mariyappa
, Jenny Harrington
, Tom Loudovaris
, Gordon Thomas
, Henry C.C. Pleass
, Alex Brown
, Thomas W. Kay
, Christopher J. Drogemuller
, David J. Torpy
, Richard Couper
, John Chen
, Patrick T. Coates

Research output: Contribution to journal › Letter › peer-review

Abstract

Hereditary pancreatitis causes severe early-onset pain and hospitalisation. In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT’s potential to improve quality of life and reduce healthcare burden. Our programme aims to build evidence to support public funding and ensure equitable access to this procedure.

Original language	English (US)
Article number	e70129
Journal	Medical Journal of Australia
Volume	224
Issue number	1
DOIs	https://doi.org/10.5694/mja2.70129
State	Published - Jan 2026
Externally published	Yes

Keywords

gene expression
paediatric surgery
pancreas transplantation
pancreatic diseases

ASJC Scopus subject areas

General Medicine

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10.5694/mja2.70129

Cite this

Radisic, G., Etherton, C., Rickard, A., Weetra, M., Wu, D., Khurana, S., Mariyappa, B., Harrington, J., Loudovaris, T., Thomas, G., Pleass, H. C. C., Brown, A., Kay, T. W., Drogemuller, C. J., Torpy, D. J., Couper, R., Chen, J., & Coates, P. T. (2026). Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience. Medical Journal of Australia, 224(1), Article e70129. https://doi.org/10.5694/mja2.70129

Radisic, G, Etherton, C, Rickard, A, Weetra, M, Wu, D, Khurana, S, Mariyappa, B, Harrington, J, Loudovaris, T, Thomas, G, Pleass, HCC, Brown, A, Kay, TW, Drogemuller, CJ, Torpy, DJ, Couper, R, Chen, J & Coates, PT 2026, 'Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience', Medical Journal of Australia, vol. 224, no. 1, e70129. https://doi.org/10.5694/mja2.70129

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title = "Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience",

abstract = "Hereditary pancreatitis causes severe early-onset pain and hospitalisation. In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT{\textquoteright}s potential to improve quality of life and reduce healthcare burden. Our programme aims to build evidence to support public funding and ensure equitable access to this procedure.",

keywords = "gene expression, paediatric surgery, pancreas transplantation, pancreatic diseases",

author = "Gorjana Radisic and Colleen Etherton and Alice Rickard and Merle Weetra and Denghao Wu and Sanjeev Khurana and Bhanu Mariyappa and Jenny Harrington and Tom Loudovaris and Gordon Thomas and Pleass, \{Henry C.C.\} and Alex Brown and Kay, \{Thomas W.\} and Drogemuller, \{Christopher J.\} and Torpy, \{David J.\} and Richard Couper and John Chen and Coates, \{Patrick T.\}",

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year = "2026",

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doi = "10.5694/mja2.70129",

language = "English (US)",

volume = "224",

journal = "Medical Journal of Australia",

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T2 - A Preliminary Evaluation of a 10-Year Experience

AU - Radisic, Gorjana

AU - Etherton, Colleen

AU - Rickard, Alice

AU - Weetra, Merle

AU - Wu, Denghao

AU - Khurana, Sanjeev

AU - Mariyappa, Bhanu

AU - Harrington, Jenny

AU - Loudovaris, Tom

AU - Thomas, Gordon

AU - Pleass, Henry C.C.

AU - Brown, Alex

AU - Kay, Thomas W.

AU - Drogemuller, Christopher J.

AU - Torpy, David J.

AU - Couper, Richard

AU - Chen, John

AU - Coates, Patrick T.

PY - 2026/1

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N2 - Hereditary pancreatitis causes severe early-onset pain and hospitalisation. In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT’s potential to improve quality of life and reduce healthcare burden. Our programme aims to build evidence to support public funding and ensure equitable access to this procedure.

AB - Hereditary pancreatitis causes severe early-onset pain and hospitalisation. In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT’s potential to improve quality of life and reduce healthcare burden. Our programme aims to build evidence to support public funding and ensure equitable access to this procedure.

KW - gene expression

KW - paediatric surgery

KW - pancreas transplantation

KW - pancreatic diseases

UR - https://www.scopus.com/pages/publications/105027820977

UR - https://www.scopus.com/pages/publications/105027820977#tab=citedBy

U2 - 10.5694/mja2.70129

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M3 - Letter

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AN - SCOPUS:105027820977

SN - 0025-729X

VL - 224

JO - Medical Journal of Australia

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IS - 1

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ER -

Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10-Year Experience

Abstract

Keywords

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