Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage

Keyphrases

• Alkylation 100%
• Site-directed 100%
• DNA Cleavage 100%
• Topoisomerase II 100%
• Guanine 20%
• Acidic pH 13%
• PH Value 13%
• DNA Adducts 13%
• Cleavage Site 13%
• DNA Complex 13%
• Antitumor Agents 6%
• DNA Alkylation 6%
• Mg2+ 6%
• Enhanced Stability 6%
• Plant-derived 6%
• Subsequent Effects 6%
• Topoisomerase II Poison 6%
• 7-Deazaguanine 6%
• Precise Location 6%
• Structural Insights 6%
• Abasic Site 6%
• Enzyme-mediated 6%
• Depurination 6%
• Excess Salt 6%

Biochemistry, Genetics and Molecular Biology

• Alkylation 100%
• DNA Cleavage 100%
• DNA Gyrase 100%
• Guanine 18%
• DNA Adduct 12%
• Enzyme 6%
• Conformation 6%
• Gene Linkage 6%
• DNA Alkylation 6%
• Depurination 6%

Pharmacology, Toxicology and Pharmaceutical Science

• DNA Topoisomerase (ATP Hydrolysing) 100%
• Guanine 18%
• Sodium Chloride 6%
• Anticarcinogen 6%
• Epileptic Absence 6%
• Magnesium Ion 6%