Topographic deficits in alpha-range resting EEG activity and steady state visual evoked responses in schizophrenia

Michael R. Goldstein, Michael J. Peterson, Joseph L. Sanguinetti, Giulio Tononi, Fabio Ferrarelli

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Deficits in both resting alpha-range (8-12. Hz) electroencephalogram (EEG) activity and steady state evoked potential (SSVEP) responses have been reported in schizophrenia. However, the topographic specificity of these effects, the relationship between resting EEG and SSVEP, as well as the impact of antipsychotic medication on these effects, have not been clearly delineated. The present study sought to address these questions with 256 channel high-density EEG recordings in a group of 13 schizophrenia patients, 13 healthy controls, and 10 non-schizophrenia patients with psychiatric diagnoses currently taking antipsychotic medication. At rest, the schizophrenia group demonstrated decreased alpha EEG power in frontal and occipital areas relative to healthy controls. With SSVEP stimulation centered in the alpha band (10. Hz), but not with stimulation above (15. Hz) or below (7. Hz) this range, the occipital deficit in alpha power was partially reverted. However, the frontal deficit persisted and contributed to a significantly reduced topographic relationship between occipital and frontal alpha activity for resting EEG and 10. Hz SSVEP alpha power in schizophrenia patients. No significant differences were observed between healthy and medicated controls or between medicated controls and schizophrenia. These findings suggest a potential intrinsic deficit in frontal eyes-closed EEG alpha oscillations in schizophrenia, whereby potent visual stimulation centered in that frequency range results in an increase in the occipital alpha power of these patients, which however does not extend to frontal regions. Future research to evaluate the cortical and subcortical mechanisms of these effects is warranted.

Original languageEnglish (US)
Article number6501
Pages (from-to)145-152
Number of pages8
JournalSchizophrenia Research
Volume168
Issue number1-2
DOIs
StatePublished - Oct 1 2015

Keywords

  • Alpha
  • EEG
  • Frontal cortex
  • Occipital cortex
  • Steady state visual evoked potential
  • Topography

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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