Tonic suppression of gastric acid secretion by endogenous peptides in neonatal rats

R. K. Rao, S. Pepperl, F. Porreca

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Stimulation of gastric acid secretion by secretagogues was measured in developing rats by in vivo and in vitro techniques. Basal acid outputs in vivo were very low in 8- and 14-day-old rats compared with those in 20- and 30-day-old rats. In 20-day-old rats, all secretagogues increased acid output in vivo, whereas only carbachol, pentagastrin, and sulfated cholecystokinin octapeptide (CCK-8S) were active in 14-day-old rats. In contrast, basal acid output in vitro and stimulation by secretagogues did not differ significantly with age. CCK-8S-stimulated acid output in vitro in 14-day-old rats was blocked by L-365,260, L-364,718, tetrodotoxin, and atropine, but not by hexamethonium, whereas gastrin-stimulated acid output was blocked only by L- 365,260. Furthermore, acid output in vivo was elevated three- to fourfold by subcutaneous naloxone-methiodide or L-364,718, but not by L-365,260, in 14- day-old rats; none of these antagonists produced an effect in 20-day-old rats. These studies show that low basal gastric acid output in neonatal rats is caused by tonic inhibitory regulation by endogenous regulatory peptides.

Original languageEnglish (US)
Pages (from-to)G721-G728
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number5 32-5
StatePublished - 1995


  • cholecystokinin
  • cholinergic
  • development
  • enteric nerves
  • gastrin
  • histamine
  • opioids
  • parietal cells
  • pentagastrin
  • receptors
  • stomach

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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