Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart

Keyphrases

• Titin 100%
• Volume Overload 100%
• Mechanotransduction 100%
• Knock-in Mouse Model 85%
• Hypertrophy 57%
• Wild Mice 42%
• FHL2 42%
• Aortocaval Fistula 28%
• FHL1 28%
• Exercise-induced 28%
• Transverse Aortic Constriction 28%
• High Mortality Rate 14%
• Genotype 14%
• Signaling Pathway 14%
• Protein Level 14%
• Isoproterenol 14%
• Left Ventricular Hypertrophy 14%
• Protein Expression Level 14%
• Pressure Overload 14%
• Hypertrophic Response 14%
• Downstream Signaling 14%
• Mechanical Load 14%
• Mechanosensor 14%
• Signaling Mediators 14%
• RNA-seq Analysis 14%
• Mechanosensing 14%
• LIM Domain 14%
• Adrenergic Response 14%
• Swim Exercise 14%
• Cardiac Overload 14%

Biochemistry, Genetics and Molecular Biology

• Titin 100%
• Knockout Mouse 100%
• Mechanotransduction 100%
• FHL2 50%
• Wild Type Mouse 50%
• FHL1 33%
• Signal Transduction 16%
• Mortality Rate 16%
• RNA Sequencing 16%
• Mediator 16%
• Protein Expression Level 16%
• LIM Domain 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Connectin 100%
• Knockout Mouse 100%
• Wild Type Mouse 50%
• Aortocaval Fistula 33%
• Aortic Constriction 33%
• Mortality Rate 16%
• Heart Left Ventricle Hypertrophy 16%
• Isoprenaline 16%