Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Henk Granzier; Dietmar Labeit; Yiming Wu; Siegfried Labeit

doi:10.1023/A:1023458406346

Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Henk Granzier
, Dietmar Labeit
, Yiming Wu
, Siegfried Labeit

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.

Original language	English (US)
Pages (from-to)	457-471
Number of pages	15
Journal	Journal of Muscle Research and Cell Motility
Volume	23
Issue number	5-6
DOIs	https://doi.org/10.1023/A:1023458406346
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physiology
Cell Biology

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title = "Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology",

abstract = "Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.",

author = "Henk Granzier and Dietmar Labeit and Yiming Wu and Siegfried Labeit",

note = "Funding Information: Supported by National Institutes of Healt h (HL61497 and HL62881 to HG) and Deutsche Forschungsgeme-inschaft (La La668/6-2 and 7-1 to SL). We thank Dr Miklos Kellermayer for review of this manuscript. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Energy Research, under Contract No. W-31-109-ENG-38.BioCAT is a U.S. National Institutes of Heal th-supported Research Center RR08630.",

year = "2002",

doi = "10.1023/A:1023458406346",

language = "English (US)",

volume = "23",

pages = "457--471",

journal = "Journal of Muscle Research and Cell Motility",

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T1 - Titin as a modular spring

T2 - Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

AU - Granzier, Henk

AU - Labeit, Dietmar

AU - Wu, Yiming

AU - Labeit, Siegfried

N1 - Funding Information: Supported by National Institutes of Healt h (HL61497 and HL62881 to HG) and Deutsche Forschungsgeme-inschaft (La La668/6-2 and 7-1 to SL). We thank Dr Miklos Kellermayer for review of this manuscript. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Energy Research, under Contract No. W-31-109-ENG-38.BioCAT is a U.S. National Institutes of Heal th-supported Research Center RR08630.

PY - 2002

Y1 - 2002

N2 - Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.

AB - Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.

UR - https://www.scopus.com/pages/publications/0038583937

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U2 - 10.1023/A:1023458406346

DO - 10.1023/A:1023458406346

M3 - Review article

C2 - 12785097

AN - SCOPUS:0038583937

SN - 0142-4319

VL - 23

SP - 457

EP - 471

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

IS - 5-6

ER -

Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Abstract

ASJC Scopus subject areas

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