@article{65105b0e717241c3835117805d4af77e,
title = "Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology",
abstract = "Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.",
author = "Henk Granzier and Dietmar Labeit and Yiming Wu and Siegfried Labeit",
note = "Funding Information: Supported by National Institutes of Healt h (HL61497 and HL62881 to HG) and Deutsche Forschungsgeme-inschaft (La La668/6-2 and 7-1 to SL). We thank Dr Miklos Kellermayer for review of this manuscript. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Energy Research, under Contract No. W-31-109-ENG-38.BioCAT is a U.S. National Institutes of Heal th-supported Research Center RR08630.",
year = "2002",
doi = "10.1023/A:1023458406346",
language = "English (US)",
volume = "23",
pages = "457--471",
journal = "Journal of Muscle Research and Cell Motility",
issn = "0142-4319",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "5-6",
}