TY - JOUR
T1 - Titin as a modular spring
T2 - Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology
AU - Granzier, Henk
AU - Labeit, Dietmar
AU - Wu, Yiming
AU - Labeit, Siegfried
N1 - Funding Information:
Supported by National Institutes of Healt h (HL61497 and HL62881 to HG) and Deutsche Forschungsgeme-inschaft (La La668/6-2 and 7-1 to SL). We thank Dr Miklos Kellermayer for review of this manuscript. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Energy Research, under Contract No. W-31-109-ENG-38.BioCAT is a U.S. National Institutes of Heal th-supported Research Center RR08630.
PY - 2002
Y1 - 2002
N2 - Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.
AB - Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.
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U2 - 10.1023/A:1023458406346
DO - 10.1023/A:1023458406346
M3 - Review article
C2 - 12785097
AN - SCOPUS:0038583937
SN - 0142-4319
VL - 23
SP - 457
EP - 471
JO - Journal of Muscle Research and Cell Motility
JF - Journal of Muscle Research and Cell Motility
IS - 5-6
ER -