Tissue microarray analysis reveals prognostic significance of syndecan-I expression in prostate cancer

Tobias Zellweger, Christoph Ninck, Martina Mirlacher, Matthias Annefeld, Andrew G. Glass, Thomas C. Gasser, Michael J. Mihatsch, Edward P. Gelmann, Lukas Bubendorf

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

BACKGROUND. Tissue microarrays (TMA) have recently emerged as powerful tools to rapidly analyze the clinical significance of new molecular markers in human tumors. Here, we have tested several molecular markers on a prostate TMA containing 637 different specimens. METHODS. The specimens were from 551 patients with prostate cancer and long-term follow-up information on progression (median 5.3 years), tumor-specific and overall survival (median 5.9 years). Eighty-six specimens from benign prostatic hyperplasia were included as controls. Expression of Ki67, Bcl-2, p53, CD-10 (neutral endopeptidase), and syndecan-1 (CD-138) was analyzed by immunohistochemistry. RESULTS. Gleason grade and Ki67 Labeling Index (LI) were independent predictors of early recurrence and poor survival. Bcl-2 predicted early recurrence, whereas p53 was associated with poor survival. Syndecan-1 overexpression also predicted early recurrence and was significantly associated with tumor specific survival, high Gleason grade, Ki67 LI, and Bcl-2 overexpression. Neoadjuvant hormonal therapy was associated with overexpression of Bcl-2 and inhibition of Ki67 LI and CD-10, but did not affect the expression of the remaining markers. CONCLUSIONS. The results of this TMA study confirm a dominant prognostic significance of Gleason grading and Ki67 LI in prostate cancer, as compared to a less pronounced role of Bcl-2, and p53. We identified syndecan-1 as a new prognostic factor and provide evidence for an androgen-dependent regulation of CD-10 expression.

Original languageEnglish (US)
Pages (from-to)20-29
Number of pages10
JournalProstate
Volume55
Issue number1
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Keywords

  • Ki67
  • Prognosis
  • Prostate cancer
  • Syndecan-1
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Urology

Fingerprint

Dive into the research topics of 'Tissue microarray analysis reveals prognostic significance of syndecan-I expression in prostate cancer'. Together they form a unique fingerprint.

Cite this