Tissue engineering a bioartificial pancreas based on transformed endocrine cells

Thanassis Sambanis, Klearchos K. Papas, Evangelos Tziampazis, Robert C. Long, Ioannis Constantinidis

Research output: Contribution to conferencePaperpeer-review


The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.

Original languageEnglish (US)
Number of pages1
StatePublished - 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995


OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA

ASJC Scopus subject areas

  • General Engineering


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