Timing is everything: Misincorporation of 8oxodg during mitosis is lethal

Khadijeh Alnajjar, Joann B. Sweasy

Research output: Contribution to journalArticlepeer-review

Abstract

Exploiting universal cancer vulnerabilities has been used as an approach for developing targeted therapies. In this issue of Cancer Research, Rudd and colleagues show that the dual-functioning inhibitor TH588 potentiates the accumulation of reactive oxygen species during mitosis in cancer by disturbing mitotic progression and simultaneously inhibiting the hydrolysis of 8oxodGTP. This leads to increased incorporation of 8oxodG into the DNA during mitotic replication and increased toxicity. Understanding the mechanism of this inhibitor lays the groundwork for identifying cancer targets.

Original languageEnglish (US)
Pages (from-to)3459-3460
Number of pages2
JournalCancer Research
Volume80
Issue number17
DOIs
StatePublished - Sep 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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