Time-to-event predictive modeling for chronic conditions using electronic health records

Yu Kai Lin, Hsinchun Chen, Randall A. Brown, Shu Hsing Li, Hung Jen Yang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Although electronic health records (EHRs) hold promise for supporting clinical decision making, few studies have used them to model the progression of chronic conditions. To examine the feasibility of EHR-based predictive models for chronic conditions and to mitigate the associated data challenges, the authors develop a time-to-event predictive modeling framework consisting of five analytical steps: guideline-based feature selection, temporal regularization, data abstraction, multiple imputation, and extended Cox models. Using concept- and temporal-abstracted features, the proposed model attained significantly improved performance over the model using only base features.

Original languageEnglish (US)
Article number6813395
Pages (from-to)14-20
Number of pages7
JournalIEEE Intelligent Systems
Issue number3
StatePublished - 2014


  • EHR
  • chronic conditions
  • electronic health records
  • intelligent systems
  • prognostic modeling
  • time-to-event predictive modeling

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Artificial Intelligence


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